Orion is a nebula and constellation in the Milky Way galaxy. There is apparently a planet of the same name, which is the home of the Orion Vivisectional Mudpuppy.
Rhaemes Tipper Quirk once made a wrong turn at Orion, on his way to the Asteroid of Doom, allowing Roger Wilco to destroy it before he could.
Behind the scenes[]
There are quite a few things named after Orion in space quest. It is also possible that the reference is to a planet named Orion, rather than the constellation. The location of Orion appears to be somewhere near the planet Labion.